Project CLEAR

MRSA Absence-Presence Dataset <br> MRSA isolates were collected as part of the CLEAR (Changing Lives by Eradicating Antibiotic Resistance) Trial. The trial was designed to compare the impact of a repeated decolonization protocol plus education on general hygiene and environmental cleaning to education alone on MRSA infection and hospitalization. Study subjects in the trial were recruited from hospitalized patients based on an MRSA positive culture or surveillance swabs. After recruitment, swabs were obtained from different body parts of subjects (nares, skin, throat, and wound) around the time of hospital discharge (ENRL) and at 1,3,6 and 9 months (V1-V4, respectively) following the initial visit, after which the swabs were cultured on chromogenic agar. The application of decolonization protocol lasted only for 6 months, and consequently, we only modeled visits until V3 in this study. We note that some enrolled study subjects, despite a positive culture (clinical or surveillance) during the hospital stay, did not have discharge swabs positive for MRSA at the first time point (ENRL). The data used in this study are collected from people aged over 18 (average age=56, SD=17) for both the education and decolonization groups, with eligibility requirements also including hospitalization within previous 30 days and positive testing for MRSA during the enrollment hospitalization or within the 30 days before or afterwards. Exclusion criteria included hospice care and allergy to the decolonization products. Over the course of the trial, 98 of 1063 participants (9.2%) in the education group and in 67 of 1058 (6.3%) in the decolonization group developed MRSA infections, and 84.8% of the MRSA infections resulted in hospitalization. More details about recruitment and eligibility, follow up, sample collection, and data preprocessing can be found in the reference https://www.nejm.org/doi/10.1056/NEJMoa1716771.耐甲氧西林金黄色葡萄球菌（MRSA）存在-缺失数据集：本数据集的MRSA分离株采集自CLEAR（通过根除抗生素耐药性改善生活）试验。该试验旨在对比两种干预方案对MRSA感染与住院的影响：其一为重复实施的去定植方案联合通用卫生与环境清洁宣教，其二为单独的卫生宣教。本试验的研究对象从住院患者中招募，招募标准为患者的MRSA培养结果或监测拭子检测呈阳性。招募完成后，分别于患者出院时（ENRL）以及首次随访后的第1、3、6、9个月（依次对应V1至V4），采集受试者不同身体部位（鼻腔、皮肤、咽喉与伤口）的拭子样本，随后将拭子接种于显色琼脂培养基进行培养。由于去定植方案的实施周期仅为6个月，因此本研究仅建模至V3随访节点的数据。需注意的是，部分入组受试者虽在住院期间的临床培养或监测拭子检测结果呈阳性，但在首次采样节点（ENRL）的出院拭子MRSA检测结果为阴性。本研究使用的数据均来自18岁以上的受试者（两组受试者平均年龄为56岁，标准差为17），其中宣教组与去定植组的入组标准还包括：入组前30天内曾住院，且在住院入组期间或入组前后30天内的MRSA检测结果呈阳性。排除标准则包括接受临终关怀，以及对去定植产品存在过敏反应。试验期间，宣教组的1063名受试者中共有98人（占比9.2%）发生MRSA感染，去定植组的1058名受试者中共有67人（占比6.3%）发生MRSA感染；其中84.8%的MRSA感染病例需要住院治疗。有关受试者招募与入组标准、随访流程、样本采集及数据预处理的更多细节，可参阅参考文献：https://www.nejm.org/doi/10.1056/NEJMoa1716771。