Assessment of a New Volumetric Capnography-derived Parameter to Reflect Compression Depth and to Predict Return of Spontaneous Circulation during Cardiopulmonary Resuscitation in a Porcine Model

This experimental cross-over study using a domestic pig model evaluated a volumetric capnography-derived parameter, the volume of CO2 eliminated per minute and per kg body weight (V’CO2kg-1), as an indicator of quality of chest compression (CC) and as a predictor of return of spontaneous circulation (ROSC) under stable ventilation status following cardiac arrest. Animals were subjected to untreated ventricular fibrillation, followed by mechanical cardiopulmonary resuscitation (CPR) and ventilation. Three types of CC quality were tested, followed by advanced life support, consecutively. We believe that our study makes a significant contribution to the literature because we showed that CC quality had a significant effect on the partial pressure of end-tidal carbon dioxide (PETCO2), V’CO2kg-1, and other hemodynamic variables. While, V’CO2 kg-1 had similar performance as PETCO2 in terms of CC quality and ability to predict to ROSC, V’CO2kg-1 requires a longer time to achieve a stable state.

本项采用家猪模型进行的交叉实验研究，评估了基于容积式二氧化碳呼气描记法所得参数——每分钟及每千克体重二氧化碳消除量（V'CO2kg-1）——作为胸部按压质量指标及在心脏骤停后稳定通气状态下预测自主循环恢复（ROSC）的预测因子。动物被施加未经治疗的室颤，随后接受机械心肺复苏（CPR）及通气。依次测试了三种胸部按压质量类型，并随后进行高级生命支持。我们坚信，本研究对文献做出了重要贡献，因为我们证明了胸部按压质量对呼气末二氧化碳分压（PETCO2）、V'CO2kg-1及其他血流动力学变量具有显著影响。同时，V'CO2kg-1在胸部按压质量及预测ROSC的能力上与PETCO2表现相似，但需更长时间方能达到稳定状态。