Total Synthesis of (+)-Fastigiatine
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https://figshare.com/articles/dataset/Total_Synthesis_of_Fastigiatine/2750746
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The first total synthesis of the Lycopodium alkaloid (+)-fastigiatine has been accomplished in 15 steps and 30% overall yield from known compounds. Noteworthy transformations include a convergent fragment coupling via a nucleophilic cyclopropane opening, a highly diastereoselective formal [3 + 3]-cycloaddition, and a transannular Mannich reaction to construct the core of the natural product.
创建时间:
2010-07-21



