OncotRF

OncotRF contains an analysis pipeline for tRF identification and characterization, analysis results of 11,211 small RNA sequencing samples and 8,776 RNA sequencing samples, and clinicopathologic annotation data from The Cancer Genome Atlas (TCGA). The results include: tRF identification and quantification across 33 cancers, abnormally expressed tRFs and genes, tRF-gene correlations, tRF-gene networks, survival analyses, and tRF-related functional enrichment analyses. Users are also able to identify differentially expressed tRFs, predict their functions, and assess the relevance of the tRF expression levels to the clinical outcome according to user-defined groups.

OncotRF 包含一套用于tRF（transfer RNA-derived fragment）鉴定与表征的分析流程，涵盖源自癌症基因组图谱（The Cancer Genome Atlas, TCGA）的11211份小RNA测序样本、8776份RNA测序样本的分析结果，以及临床病理注释数据。该数据集的分析结果包括：33种癌症中的tRF鉴定与定量分析、异常表达的tRF与基因、tRF-基因关联分析、tRF-基因网络、生存分析，以及tRF相关功能富集分析。用户还可自定义分组，鉴定差异表达的tRF、预测其功能，并评估tRF表达水平与临床结局的相关性。

搜集汇总

背景与挑战

背景概述

OncotRF是一个全面的tRFs数据库，专注于癌症研究，整合了11211个样本和6966个tRFs的数据，提供详细的tRF信息、差异表达分析、功能分析和生存分析等功能，旨在帮助识别癌症诊断和预后的生物标志物。