Drug-induced Rosacea: A Systematic Review

Rosacea is a common cutaneous inflammatory disorder characterized by a heterogenous mix of features including erythema, papules, pustules, phymatous changes, telangiectasia and ocular manifestations, that may occur in response drug therapy. Documentation in the literature of drug-induced cases of rosacea, most commonly corticosteroid therapy, indicate that a potential rebound vasodilatory reaction from pro-inflammatory cytokine release may play a role in rosacea pathogenesis. Identifying and mitigating adverse events from drug therapy is important to treatment adherence in patients and to prevent unnecessary harm. This systematic review investigates the onset of rosacea in patients receiving drug therapy.