Eicosanoid metabolism via cyclooxygenases (COX)

This pathway is inspired by the Lipidmaps>Eicosanoids Pathway expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with the top left side of Figure 1 from Dennis and Norris (2015 [https://www.ncbi.nlm.nih.gov/pubmed/26139350]). Eicosanoids are a large group of compounds metabolised from arachidonic acid (AA), either via cyclooxygenases (COX)[https://www.wikipathways.org/index.php/Pathway:WP4347], lipooxygenases(LOX)[https://www.wikipathways.org/index.php/Pathway:WP4348], or cytochrome P450 monooxygenases (CYP)[https://www.wikipathways.org/index.php/Pathway:WP4349]. This pathway visualises the first route, via COX, where additonal colours have been used to visualise which conversions are being performed by the same enzymes. Green and orange boxes represent receptors, where the orange colour depicts peroxisome-proliferator activating receptors (PPARs) potentially activated by the eicosanoids.

本路径受到Lipidmaps>Eicosanoids路径扩展路径显示的启发，并扩展了Dennis和Norris（2015年[https://www.ncbi.nlm.nih.gov/pubmed/26139350]）图1的左上角。二十烷类化合物是一大类从花生四烯酸（AA）代谢而来的化合物，其代谢途径包括环氧化酶（COX）[https://www.wikipathways.org/index.php/Pathway:WP4347]、脂氧合酶（LOX）[https://www.wikipathways.org/index.php/Pathway:WP4348]或细胞色素P450单加氧酶（CYP）[https://www.wikipathways.org/index.php/Pathway:WP4349]。该路径可视化了第一条途径，即通过COX，其中采用了额外的颜色来表示由相同酶进行的转化。绿色和橙色方框代表受体，其中橙色表示可能被二十烷类化合物激活的过氧化物酶体增殖因子激活受体（PPARs）。