In vivo Study of the Effects of a Northern Contaminant Mixture (NCM) on the Development of Metabolic and Cardiovascular Diseases under Conditions Typifying the Diets and Lifestyles of Northerners

This is a toxicological study using animal models. In this study, obese and lean JCR rats are treated orally with alcohol or high fat/sugar diet and a mixture of 22 contaminants found in the Inuit blood. After four weeks of daily dosing, the animals were sacrificed. Blood, urine, and organs were collected and analyzed for contaminant levels, lipid profile, and markers of organ toxicity, cardiovascular and metabolic diseases.