Investigation of Adipose Derived Exosomal miRNA in Intrauterine BPA Exposure Leading to Obesity in Male Offspring Mice

Environmental relevant concentrations of intrauterine BPA exposure may increase body mass and contribute to obesity. Here, a mouse model was designed to examine the impact of exosomes on the development of obesity in male offspring mice that were exposed to intrauterine BPA at a dosage of 0.05 mg/kg/day. We discovered that intrauterine BPA exposure resulted in obesity in male offspring mice and identified an adipose-derived exosome miRNA miR-124-3p.