Construct a ceRNA regulatory network to explore potential pathogenesis and therapy options of human hepatocellular carcinoma

The human circRNA profiles of Hepatocellular carcinoma are rarely reported. Surgically removed human HCC tissues and matched normal liver tissues (5cm away from tumor) were collected to make an Agilent microarray. Five paired of human HCC tissues and normal controls were collected. All patients have no radiotherapy or chemotherapy before surgery. None of these five patients have distant metastasis. It provides new markers and therapeutic targets for the diagnosis and treatment of hcc