Stereoselective Three-Component Allylic Alkylation Enabled by Dual Photoredox/Ni Catalysis

A modular and practical approach
has been developed for
the stereoselective
formation of elaborate allylic alcohols through a three-component
reaction (3CR) between vinyl cyclic carbonates, olefins, and various
radical precursors using dual photoredox/Ni catalysis. The developed
process expands the potential of radical-based allylic alkylation
to multicomponent approaches under high regio- and stereocontrol with
ample variation of the individual reagents and offers access to compounds
featuring sterically congested and functionalized quaternary carbon
centers. The catalytic protocol can be expanded to other allylic precursors,
and the stereoselectivity is reversed by simply changing the photocatalyst.