CARD9 binds RIP2 (and NOD2)

CARD9 binds RIP2 and NOD2. In addition overexpression of CARD9 strongly activates the kinases p38 and Jnk while CARD9-deficient mouse macrophages have defects in activation of p38 and Jnk but not NF-kappaB signaling, suggesting that CARD9 is involved in an NF-kappaB-independent signaling pathway (Hsu et al. 2007), but the mechanism is unclear. CARD9 is the key transducer of signals from dectin-1, the major mammalian pattern recognition receptor for the fungal component zymosan (Gross et al. 2006).

CARD9能够与RIP2和NOD2结合。此外，CARD9的过表达显著激活了p38和Jnk激酶，而CARD9缺陷型小鼠巨噬细胞在p38和Jnk的激活方面存在缺陷，但在NF-κB信号通路中则未受到影响，这表明CARD9参与了一条非NF-κB依赖的信号通路（Hsu等人，2007年），但其机制尚不明确。CARD9是dectin-1信号的关键传递者，dectin-1是哺乳动物中主要的真菌成分胞壁质识别受体（Gross等人，2006年）。