Datasets used in generating Figure 7 of Button et al., 2025 The 1 –Cys peroxiredoxin, PRDX-6, suppresses an NHR-49-dependent pro-survival response, including the Flavin monoxygenase, FMO-2, that protects against fungal and bacterial infection.

Datasets used to generate panels in <b>Figure 7: NHR-49 is required for induction of </b><b><i>fmo-2</i></b><b> in response to </b><b><i>C. albicans </i></b><b>leading us to propose that NHR-49 mediates the effect of loss of </b><b><i>prdx-6</i></b><b> on </b><b><i>fmo-2 </i></b><b>expression an stress resistance and innate immunity</b> in Button et al. 2025 https://doi.org/10.1016/j.redox.2025.103992Figure 7A: Excel file containing analysis of the intestinal expression of the <i>fmo-2P::gfp</i> reporter gene in wild-type and <i>nhr-49</i> (<i>nr2041</i>) mutant <i>C. elegans </i>before and following 18h <i>C. albicans</i> exposure. This dataset is representative of multiple independent experiments involving at least 20 animals in each group.Figure 7C: Excel file containing analysis of the survival of L4 stage wild-type, <i>prdx-6</i>(<i>tm4225</i>), <i>fmo-2</i>(<i>ok2147</i>)<i> </i>and<i> </i><i>prdx-6</i>(<i>tm4225</i>)<i> </i><i>fmo-2</i>(<i>ok2147</i>) mutant animals following transfer to plates containing 5mM sodium arsenite. This dataset is representative of multiple independent experiments involving at least 40 animals in each group.Figure 7D: Excel file containing analysis of the survival of L4 stage wild-type (N2), <i>prdx-6</i>(<i>tm4225</i>), <i>fmo-2</i>(<i>ok2147</i>)<i> </i>and<i> </i><i>prdx-6</i>(<i>tm4225</i>)<i> </i><i>fmo-2</i>(<i>ok2147</i>) mutant animals at 15^oC. This dataset is representative of multiple independent experiments carried out in the presence of FUDR.Figure 7E: Excel file containing analysis of the survival of L4 stage wild-type, <i>prdx-6</i>(<i>tm4225</i>), <i>fmo-2</i>(<i>ok2147</i>)<i> </i>and<i> </i><i>prdx-6</i>(<i>tm4225</i>)<i> </i><i>fmo-2</i>(<i>ok2147</i>) mutant animals following infection with <i>Staphylococcus aureus</i>. This dataset is representative of multiple independent experiments.Figure 7F: Excel file containing analysis of the number of viable or unhatched eggs laid by wild-type (N2), <i>prdx-6</i>(<i>tm4225</i>), <i>nhr-49</i>(<i>nr2041</i>) and <i>prdx-6</i>(<i>tm4225</i>) <i>nhr-49</i>(<i>nr2041</i>) mutant <i>C. elegans </i>maintained on NGM-L plates on NGM-L plates containing 0.8mM oleate. This dataset is representative of two independent experiments.These are part of collection https://doi.org/10.25405/data.ncl.c.8231413<br><br><br><br><br>