SLC28C2,3 cotransports RBV, Na+ from extracellular region to cytosol

The concentrative sodium/nucleoside cotransporters 2 and 3 (CNT2, SLC28A2 and CNT3, SLC28C3) import ribavirin (RBV) together with sodium ions (Na+) into cells. As the transporters are expressed on the plasma membranes of many cell types, RBV may be absorbed extensively (Errasti-Murugarren et al, 2007; Podgorska et al, 2005). Kinetic studies in Xenopus laevis oocytes point to a possible interaction of SLC29A1 with the SLC28A3 transport process (Yamamoto et al, 2010). Presence of interferon-alpha (IFNA) enhances uptake by apparent promotion of SLC28A2 translocation to the plasma membrane (probably by upregulation of SLC28A2 expression), which explains synergistic effects in treatment with both drugs (Pinilla-Macua et al, 2014).

钠/核苷共转运蛋白2和3（CNT2，SLC28A2和CNT3，SLC28C3）将利巴韦林（RBV）及其钠离子（Na+）共同转运进入细胞内。鉴于这些转运蛋白广泛表达于多种细胞类型的质膜上，RBV的吸收可能相当广泛（Errasti-Murugarren等，2007；Podgorska等，2005）。在非洲爪蟾卵母细胞中的动力学研究指出，SLC29A1可能与SLC28A3的转运过程存在可能的相互作用（Yamamoto等，2010）。干扰素-α（IFNA）的存在通过促进SLC28A2向质膜转位（可能通过上调SLC28A2的表达）增强其摄取，这解释了两种药物联合治疗时的协同作用（Pinilla-Macua等，2014）。