Amyloid PET imaging in self-identified non-Hispanic Blacks from the Anti-Amyloid in Asymptomatic Alzheimer’s Disease (A4) Study – Supplementary Data

The goal of the manuscript was to examine whether amyloid PET in CN
individuals that were screened for the Anti-Amyloid in Asymptomatic AD
(A4) study differed across self-identified, non-Hispanic White and Black
(NHW and NHB) groups.  We examined 3685 NHW and 144 NHB that
passed initial screening for the A4 study and underwent amyloid PET. The
effect of race on amyloid PET was examined using logistic (dichotomous
groups) and linear (continuous values) regression controlling for age,
sex, and number of APOE ε4 and APOE ε2 alleles. Lifestyle factors and
medical conditions were available for the majority of individuals that
received an amyloid PET scan. Additional sensitivity analyses were run to
examine potential effects between amyloid and lifestyle as well as
self-reported medical conditions that differed by race. Reduced amyloid
was observed in self-identified non-Hispanic Blacks that passed initial
eligibility criteria for the A4 Study, but lifestyle and vascular factors
did not impact this effect. This work stresses the importance of
investigating AD biomarkers in ancestrally diverse samples as well as the
need for careful consideration regarding study eligibility criteria in AD
prevention trials.