Activation of beta-catenin in hepatocellular carcinoma (mouse Ctnnb1 knockout)

CTNNB1 is the most frequently mutated gene in hepatocellular carcinoma (HCC). However, its clinical relevance remains controversial. We determined an evolutionarily conserved β-catenin signature by comparative analysis of gene expression data from human HCC (GSE43619) and a mouse model. We generated gene expression data from 4 tumor tissues from a mouse Ctnnb1 knockout model (Ctnnb1 flox(ex3)/+) and 4 normal liver tissues from control wild-type mice.