Stereoselective Radical Amination of Electron-Deficient C(sp3)–H Bonds by Co(II)-Based Metalloradical Catalysis: Direct Synthesis of α‑Amino Acid Derivatives via α‑C–H Amination

The cobalt(II) complex of 3,5-DitBu-IbuPhyrin, [Co(P1)], is an effective catalyst for intramolecular amination of electron-deficient C–H bonds, including those adjacent to electron-withdrawing CO2R, C(O)NR2, C(O)R, and CN groups, in excellent yields with high regio- and stereoselectivity. The [Co(P1)]-catalyzed amination system provides a direct method for the synthesis of α-amino acid derivatives from the corresponding carboxylate precursors.