Transcriptome dysregulation in hepatoblastomas: the pivotal role of noncoding RNAs and detection of altered lipid metabolism. Transcriptome dysregulation in hepatoblastomas: the pivotal role of noncoding RNAs and detection of altered lipid metabolism

We report the application of the RNA sequencing technology for profiling gene expression alterations in hepatoblastomas. Comparing 14 hepatoblastomas to a group of control liver samples, a set of 1492 differentially expressed genes (DEGs) was detected, both coding and non-coding. We describe the enrichment of specific biological processes related to up- and downregulated genes, and the disruption of metabolic pathways including lipids, amines, and nicotinamides. Finally, we disclose a robust ncRNA transcriptome perturbation, highlighting a new epigenetic player in the control of gene expression in hepatoblastomas. Overall design: Comparative analysis of RNA sequencing data from 14 hepatoblastomas and 05 normal liver samples.