Long-term absence of Langerhans cells alters the gene expression 2 profile of keratinocytes and dendritic epidermal T cells

In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells (LCs) led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells A total of 11 samples are included in this study with 3 replicates each fpr LC-/- and WT groups in the KC cell population and 3 replicates for WT and 2 replicates for LC-/- groups in the DETC cell population