Number of GWAS associations replicated by each method.

Number of associations identified in re-analysis of WTCCC datasets that replicate associations from either independent or non-independent GWAS. A study is considered to be independent if it does not incorporate data from the WTCCC. An associated marker is considered to replicate a known susceptibility locus if it is within 0.1 cM a marker [6] reported as an association for the same phenotype in the HuGE database. Numbers in parentheses indicate the number of hits that are distinct from those found by the single marker test.