Clec7a

Enables (1->3)-beta-D-glucan binding activity; (1->3)-beta-D-glucan immune receptor activity; and opsonin binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and response to fungus. Acts upstream of or within several processes, including phagocytosis; regulation of calcineurin-NFAT signaling cascade; and regulation of gene expression. Located in external side of plasma membrane. Is expressed in several structures, including gut; limb; musculature; spleen; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Nov 2024]

激活（1->3）-β-D-葡萄糖甘露聚糖结合活性；（1->3）-β-D-葡萄糖甘露聚糖免疫受体活性；及调理素结合活性。参与多种生理过程，包括细胞因子生产的正向调控；细胞内信号转导的正向调控；以及对真菌的反应。在吞噬作用；钙调神经磷酸酶-NFAT信号级联反应的调控；以及基因表达的调控等过程中发挥上游作用或位于其中。定位于质膜外部。在多个结构中表达，包括肠道；肢体；肌肉组织；脾脏；以及腹侧灰质。人类该基因的直系同源基因与曲霉病和慢性黏膜皮肤念珠菌病有关。与人类CLEC7A（含C型 lectin结构域的7A）同源。[由基因组资源联盟提供，2024年11月]