Synthesis of Novel C6-Phosphonated Purine Nucleosides under Microwave Irradiation by SNAr−Arbuzov Reaction

Novel C6-phosphonated purine nucleosides were obtained
in good to excellent isolated yields by the simple and catalyst-free SNAr−Arbuzov reaction of trialkyl phosphite with
6-choloropurine nucleosides, including a series of nonsugar
carbon nucleosides. Shorter reaction times were needed, and
substantially higher yields were obtained under microwave
irradiation conditions compared with conventional heating
conditions.