Heteroplasmic association with age and body mass index (BMI).

Odds ratios and corresponding p-values are reported using robust logistic regression. Heteroplasmy status is regressed upon age and BMI with univariate analyses odds ratios (OR) and model-fit likelihood ratio test (LRT) p-values presented. Adjusted odds ratios (OR) and p-values are also presented for the corresponding multiple regressions for age+BMI. Odds ratios are reported as quartiles of age and BMI (first column), with the model fit statistics (p-value) reported using the more informative continuous measures of age and BMI (second column). The p-value column reported with prevalence corresponds to the regression beta-coefficient p-values for age and BMI and multiple regression model-fit LRT p-value, respectively, with heteroplasmy regressed upon dichotomised age and BMI (upper and lower quartiles). Four individuals are observed with HVII point mutations (all 4 individuals have a BMI over 28). Twenty-two individuals are observed with VRII insertion-deletions in blood and buccal samples (between base pairs 523 to 524) and an additional 3 mutations were observed at this site in buccal samples only.