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Genome-wide maps of Dnmt3a1 binding in WT and Tet1-/- J1 ES cells

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NIAID Data Ecosystem2026-05-26 收录
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By biotin-streptavidin ChIP, we found that Dnmt3a1 enriched at diatal promoter regions and its binding was elevated by Tet1 deletion. Overall design: Biotin-tagged Dnmt3a1 J1 ES cell line were generated and Tet1 was deleted in the cell by CRISPR-Cas9. Then biotin-streptavidin ChIP-seq was performed in these cell lines.

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2018-08-21
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