Transcriptome profiling of vitamin E effect in a Caenorhabditis elegans model of mitochondrial complex I deficiency.. Caenorhabditis elegans

Although the molecular mechanisms responsible for the pathogenesis of mitochondrial disease processes vary, increased oxidative stress is a common element in many mitochondrial disorders. We used the gas-1(fc21) nematode model of complex I deficiency to test the efficacy and mechanism by transcriptome profiline of a common antioxidant, vitamin E.