Transcriptomic profiles of myometrial PGR deficient and control mouse uteri at gestation day 13

Progesterone signaling is crucial for pregnancy. To investigate the role of myometrial progesterone receptor in support of pregnancy, genome-wide gene expression profiles of pregnant uterine tissues from myometrial PGR knockout and control mice were profiled by RNAseq. The transcriptomic alterations in response to PGR loss permit identification of the underlying molecular mechanisms by which progesterone and PGR control myometrial homeostasis for pregnancy. Overall design: Mouse uterine tissues surrounding the embryo implantation sites at gestation day 13 were subject to RNA-seq analysis.