SDK1 homophillic interaction

SDK1 and SDK2 are homophilic adhesion molecules. Cells expressing them exhibit a strong preference to interact exclusively with cells expressing the same sidekick form. The N-terminal four Ig domains are arranged in a horseshoe conformation and mediate homophilic adhesion, with Ig1-2 conferring the majority of binding affinity and differential specificity.

SDK1和SDK2为同源亲和连接分子。表达这些分子的细胞表现出对仅与表达相同伴分子形式的细胞进行特异性交互的强烈偏好。其N端四个Ig结构域呈马蹄形排列，介导同源亲和连接，其中Ig1-2赋予主要的结合亲和力和差异特异性。