SNP-induced overexpression of HIF-1α and VEGF in the SNP-injected hypoderm of mice (n = 3).

Note: The immunohistochemical analysis was performed after 12 d for hypodermal sections of mice with daily injection of SNP (once a day), and the injected valume of SNP was 200 µl in all groups of treatments. The immunohistochemical staining strength was calculated from the formula of the surface density×the positive unit (PU), where the surface density represents the total area of positive loci/the total area for calculation. The singular asterisk (*) represents statistically significant difference from the control (PP