Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease
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Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease Descriptor: Protease, SODIUM ION, ZINC ION Authors: Fischmann, T.O, Prongay, A.J, Madison, V.M, Yao, N. Deposit date: 2006-12-12 Release date: 2007-10-09 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization J.Med.Chem., 50, 2007
创建时间：
2006-12-12
