Bilateral Ovarian Malignant Brenner Tumour : A Case Report With Literature Review

Brenner tumor of the ovary is very rare, mostly benign, small, and unilateral. Malignant brenner tumor (MBT) is much rarer. We present a patient aged 50 years, with no specific pathological history who presented in consultation for chronic pelvic pain. Pelvic ultrasound demonstrated a bilateral latero-uterine mass of suspicious appearance with local infiltration with peritoneal carcinosis and an ascites of average abundance. The pathological examination had concluded in a bilateral brenner tumor, endometrium, omentum are all invaded. Brenner tumors are rare ovarian tumors, first described by McNaughton-Jones in 1898 and then named by Frits Brenner in 1907. MBT presents similarly to other ovarian cancers (abdominal distension, abdominal pain, bulk symptoms and relative vague symptomatology).All histopathological diagnoses were performed according to the criteria described by Hull and Campbell. Tumors express several immunohistochemical markers of urothelial differentiation including uroplakin III, thrombomodulin, GATA3, p63, as well as cytokeratin 7. The primary treatment modality is surgical excision. This study discussed the clinical, pathological characteristics and treatment of MBTs