Bile acid therapeutics for NASH

We studied the effect of AAV8-TBG-FGF15 and GSK2330672 (8mg/kg/day), alone or in combination, against diet-induced NASH and fibrosis in mice Male C57BL/6J mice were fed chow or high fat (40% Kcal), high cholesterol (2%) and high fructose (20%) (HFCFr) diet for 32 weeks (Research Diet Inc.). AAV8-TBG-FGF15 (tail vein injection) and GSK2330672 (8 mg/kg/day, mixed with diet) treatment were initiated after 20 weeks of HFCFr diet feeding. Each experimental group contains 5 mice.