Additional file 13 of DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

Additional file 13: Table S9. Results of the sex interaction analysis. Results for all 148 replication CpG site-metabolic measure associations are shown for models identical to the discovery, but with additional “sex × methylation” interaction term. Presented are the obtained coefficient (interaction_coef) for the term of the interaction between methylation and sex (0: male, 1: female), standard error of the coefficient (interaction_SE), p value of the coefficient (interaction_P), the Bonferroni-corrected p value of the coefficient (interaction_bonf_p), the methylation-metabolite measure coefficient for males (coef_CpG_Met_male), with the calculated females coefficient (coef_CpG_Met_female, i.e., coef_CpG_Met_male + interaction_coef), and number of observations for the model (N). No interaction coefficient results pass a Bonferroni-corrected p value threshold of 0.05/148 ~ 3.4e−4 for statistical significance. All coefficients are change in natural-log transformed metabolite measurement unit (as given in Additional file 1: Table S1) per unit increase in methylation (beta value on 0–1 scale).