CEBPA binds MYC gene:E2F1

CEBPA interacts with E2F1 (Keeshan et al. 2003) bound to the promoter of the MYC gene (Johansen et al. 2001, D'Alo' et al.2003, also inferred from mouse homologs). CEBPA inhibits the transcriptional activation activity of E2F1 and inhibits transcription of MYC. By inhibiting MYC, CEBPA inhibits cell proliferation and promotes differentiation (Johansen et al. 2001, D'Alo' et al. 2003). The N terminus of the p42 isoform of CEBPA is required for interaction with E2F factors (inferred from mouse homologs) and therefore the p30 isoform, which lacks the N terminus, has a reduced ability to inhibit proliferation.

CEBPA与E2F1（Keeshan等人，2003年）相互作用，该E2F1结合于MYC基因的启动子区域（Johansen等人，2001年；D'Alo'等人，2003年；亦从小鼠同源基因推断）。CEBPA抑制E2F1的转录激活活性，并抑制MYC的转录。通过抑制MYC，CEBPA抑制细胞增殖并促进分化（Johansen等人，2001年；D'Alo'等人，2003年）。CEBPA的p42异构体的N端对于与E2F因子的相互作用是必需的（从小鼠同源基因推断），因此缺少N端的p30异构体抑制增殖的能力降低。