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Cosolvent Effects Question the Role of Water in Native Chemical Ligation

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Figshare2025-12-08 更新2026-04-28 收录
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Guanidine hydrochloride and acetonitrile strongly inhibit native chemical ligation (NCL). These effects, considered alongside the impact of the cosolvents on the water structure, suggest that water actively participates in NCL.

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2025-12-08
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