Gene expression profiling of mucosal biopsies from pediatric patients with moderately to severely active ulcerative colitis

To acquire a better understanding of the molecular pathogenesis of pediatric UC with different disease extent, we performed mRNA microarray studies to compare gene expression of patients with extensive UC vs. that of patients with limited UC. No significant difference was observed in mRNA expression between extensive and limited UC in pediatric patients. Mucosal biopsy samples (13 extensive and 6 limited UC) were collected for RNA extraction and microarray analysis.