Biodistribution of endogenous transition metals in zebrafish embryo under redox modulating conditions
收藏ESRF Portal2027-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-1830139478
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资源简介：
Previous findings established the importance of tuned redox level in the zebrafish embryo development, a process that is highly dependent on metal-bearing metalloproteins, that can modulate reactive oxygen species (ROS) levels. In this project, we want to tackle the topic of ROS level impact on the biodistribution, bioavailability and oxidation state of four endogenous metals, namely manganese (Mn), iron (Fe), copper (Cu) and zinc (Zn). To do so, we would like to perform micro-Xray fluorescence (XRF) and X-ray absorption near-edge structure (XANES) spectroscopy on sagittal sections of 24 hours old zebrafish embryos with varying ROS levels (normal, high and low). This work would be a pioneer work on the regulation of metal homeostasis by ROS levels, and would thus offer a new light on the importance of endogenous metals in the earlier stages of embryo development.
提供机构：
Sorbonne Universite,Laboratoire des Biomolecules,Departement de Chimie ENS,24 rue Lhomond,75005 PARIS,75005,PARIS,FRANCE; Sorbonne Universite,Laboratoire des Biomolecules,Laboratoire des Biomolecules Departement de Chimie ENS 24 rue Lhomond null 75005,75005,PARIS,FR; Sorbonne Universite
创建时间：
2027-01-01
