<b>A posterior insular cortex descending circuit</b><b> </b><b>modulates neuropathic pain</b>

A critical role of pIC^Glu neurons in response to neuropathic pain and reveal a previously uncharacterized long-range pathway, the pIC^Glu-RVM^GABA-DH^GABA circuit, that governs descending pain-sensory control.

本研究揭示了谷氨酸能pIC神经元（pIC^Glu）在神经病理性疼痛应答中的关键作用，并发现了一条此前未被表征的长程神经通路——谷氨酸能pIC-γ-氨基丁酸能延髓头端腹内侧区（rostral ventromedial medulla, RVM）-γ-氨基丁酸能脊髓背角（dorsal horn, DH）环路（pIC^Glu-RVM^GABA-DH^GABA），该环路介导下行疼痛感知调控。