ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

ChEBI2015-09-21 更新2026-07-12 收录

造血干细胞维持机制

基因调控干细胞分化

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-69873 数据链接链接失效反馈

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ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

创建时间：

2015-09-21

Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance

造血干细胞维持机制

Thpo/Mpl信号通路

Thrombopoietin (Thpo) signals via its receptor Mpl and regulates megakaryopoiesis, hematopoietic stem cell (HSC) maintenance and post-transplant expansion. Mpl expression is tightly controlled and der

NIAID Data Ecosystem50

Gene expression at single cell level in human umbilical cord blood cells enriched for hematopoietic stem cells and cultured in conditions that maintain HSCs ex vivo.. Gene expression at single cell level in human umbilical cord blood cells enriched for hematopoietic stem cells and cultured in conditions that maintain HSCs ex vivo.

造血干细胞维持机制

单细胞转录组学

The capacity for self-renewal of human hematopoietic stem cells (HSCs) is lost upon typical culture conditions, which often include high levels of multiple hematopoietic cytokines, serum, and/or suppo

NIAID Data Ecosystem20

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition

造血干细胞维持机制

JAK-STAT信号通路调控

Adult hematopoietic stem cells (HSCs) are responsible for the lifelong production of blood and immune cells and must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highly

NIAID Data Ecosystem10

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation. Mus musculus

造血干细胞维持机制

转录因子功能研究

To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were d

NIAID Data Ecosystem30

scRNA-seq of mouse bone marrow cells

单细胞测序

造血干细胞维持机制

sequencing was performed to elucidate the molecular mechanisms by which distinct subpopulations sustain hematopoietic stem cell (HSC) stemness.

NIAID Data Ecosystem20