The MLL-Menin interaction is a molecular dependency in NUP98-rearranged AML [ChIP-Seq]
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE175595
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资源简介：
Using mouse and human models of NUP98-rearrranged leukemia, we demonstrate that inhibition of MLL-Menin impairs leukemogenic gene expression and disrupts chromatin binding of MLL1 and NUP98 fusion proteins at a critical subset of genes that is essential for sustaining the undifferentiated leukemia phenotype. Examination of gene expression changes in mouse leukemia cells treated with the MLL-Menin inhibitor VTP50469
创建时间：
2025-07-30
