Role of Macrophage migration inhibitory factor (MIF) in pancreatic stellate cells (PSCs)

The presence of activated pancreatic stellate cells (PSCs) in the pancreatic ductal adenocarcinoma (PDAC) microenvironment plays a significant role in cancer progression. Macrophage migration inhibitory factor (MIF) is overexpressed in PDAC tissues and expressed by both cancer and stromal cells. The expression status of MIF and its receptors in PDAC- associated fibroblasts or PSCs and its pathophysiological roles are yet to be elucidated. The next-generation sequencing technique was adapted to check the effect of MIF absence on the expression of other genes in mice (mPSCs).活化胰腺星状细胞（PSCs）在胰腺导管腺癌（PDAC）微环境中的存在，在癌症进展中发挥关键作用。巨噬细胞迁移抑制因子（MIF）在PDAC组织中呈过表达状态，且由肿瘤细胞与基质细胞共同表达。目前，MIF及其受体在PDAC相关成纤维细胞或PSCs中的表达状态，以及其病理生理作用均尚未阐明。本研究采用下一代测序技术，探究MIF缺失对小鼠胰腺星状细胞（mPSCs）中其他基因表达的影响。