RNA sequencing reveals that methionine supply during late-gestation alters neonatal Holstein heifer calf liver transcriptome profiles

Maternal methionine supply during late pregnancy can affect offspring growth and development via nutritional programming. In the present study, we investigated if increasing the supply of methionine during late-pregnancy in Holstein cows affects transcriptome profiles in the offspring. Overall design: Liver biopsies were harvested at 4 days of age from 6 calves per treatment born to cows fed a control diet or the control plus ethyl-cellulose rumen-protected methionine for the last 28 days prepartum, and were fed and managed similarly after birth