Estimated Fold Changes (FC) with their respective p-values comparing the expression of each gene pre-MDA (time-points 1,2 and 3) and post-MDA (time-point 4).

A FC of >1 indicates increased expression of the gene after MDA. Column 1 includes all participants, columns 2 and 3 show the results stratified by whether an individual actually received the treatment or not. The final column (p-value for interaction) assesses the evidence as to whether the fold change from before to after MDA is different in the treated and untreated groups. Results are ordered by FC of ‘‘All” individuals (column 1).