Additional file 14 of H4-methylation regulators mediated epitranscriptome patterns and tumor microenvironment infiltration characterization in hepatocellular carcinoma

Additional file 14. Table S1. Basic information of hepatocellular carcinoma (HCC) datasets and external immunotherapy datasets included in this study. Table S2. Source and function of 36 histone H4 methylation (H4M) related regulators. Table S3. Primer sequences for qPCR. Table S4. The siRNA duplex sequences for functional experiments. Table S5. Microenvironment subtypes of HCC patients in TCGA. Table S6. Immune subtypes of HCC patients in TCGA. Table S7. TP53 mutation status of HCC patients in TCGA. Table S8. Intratumor heterogeneity score, proliferation score and Homologous Recombination Defects (HRD) score of HCC patients in TCGA-LIHC cohort. Table S9. UniCox regression and KM analyses for 36 H4M regulators. Table S10. Correlation analysis for 36 H4M regulators in meta-cohort. Table S11. Samples clustering in HCC RNA-seq meta cohorts. Table S12. Samples clustering in integrated external HCC cohorts. Table S13. Enrichment score of hallmark gene sets in HCC RNA-seq meta cohorts by GSVA analysis. Table S14. Enrichment score of HCC RNA-seq meta cohorts in cancer-related signatures. Table S15. Enrichment score of HCC RNA-seq meta cohorts in immune cell infiltration or immune signatures. Table S16. UniCox regression analysis for 133 hub genes. Table S17. The mRNA stemness index (mRNAsi) of HCC RNA-seq meta cohorts. Table S18. Immune response prediction by TIDE database. Table S19. Immunophenotype score predicted by TCIA database.