Quantitative analysis of miRNAs in irradiated/unirradiated pancreatic cancer cell

miRNA was revealed to play important role in regulating radiation response. We performed miRNA-sequencing in pancreatic cancer cell lines to identify the significantly changed miRNAs after 10Gy irradiation. Results showed that miRNAs are significantly changed in pancreatic cancer cells after radiation, 21 miRNAs were significantly upregulated, while 12 were downregulated. Further investigation revealed that there miRNA changes play vital roles in radioresistance and tumor repopulation.