Chronic lung allograft dysfunction (CLAD) is the leading cause of death in lung transplant recipients. CLAD is characterized clinically by a persistent decline in pulmonary function and histologically
The goal of the study is to characterize the bacteriome of the respiratory tract in long-term survivors of lung transplants as compared to those with chronic lung allograft dysfunction.
Rationale: Chronic lung allograft dysfunction (CLAD) is the leading cause of late-stage failure in lung transplant recipients, characterized by progressive airway fibrosis and graft dysfunction.