Additional file 11 of Rewiring of the inferred protein interactome during blood development studied with the tool PPICompare

Table S10. Enrichment of hematopoiesis-specific protein-sets. Listed are the results of hematopoiesis-specific protein-set enrichment analyses for each developmental transition. Query protein-sets were the set of all proteins in the differential network (termed “all”) and the reduced set derived by the internal optimization procedure (termed “reduced”) in the respective transition. We tested the enrichment of the query sets regarding hematopoiesis proteins and the regulatory targets of hematopoietic transcription factors (first sheet, abbreviated as “Hemato. proteins + reg. targets”), hematopoiesis proteins (second sheet, abbreviated as “Hemato. proteins”), and hematopoietic transcription factors (third sheet, abbreviated as “Hemato. TFs”). Furthermore, we determined which transcription factors (not restricted to hematopoietic transcription factors) had more regulatory targets than expected by chance in the queried set (fourth sheet, abbreviated as “Enriched hemato. TF”). The exact methodology is described in the “Methods” section. Here, significance was reported if adj.p<0.05. In all tables, test cases that were not significant ((adj.)p≥0.05) were highlighted in red. Very small p-values were reported as 0.0 due to numerical reasons (computed in Python using SciPy version 0.17 [114]). (XLSX 15.5 kb)