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Enantioselective Friedel–Crafts Alkylation Reactions of 3‑Substituted Indoles with Electron-Deficient Alkenes

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NIAID Data Ecosystem2026-03-09 收录
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https://figshare.com/articles/dataset/Enantioselective_Friedel_Crafts_Alkylation_Reactions_of_3_Substituted_Indoles_with_Electron_Deficient_Alkenes/3114916
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Highly enantioselective Friedel–Crafts C2-alkylation reactions of 3-substituted indoles with α,β-unsaturated esters and nitroalkenes were developed using chiral Lewis acids as catalysts, which afforded chiral indole derivatives bearing C2-benzylic stereogenic centers in good to excellent yields (up to 99%) and enantioselectivities (up to 96% ee).
创建时间:
2016-03-28
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