Enantioselective Friedel–Crafts Alkylation Reactions of 3‑Substituted Indoles with Electron-Deficient Alkenes
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https://figshare.com/articles/dataset/Enantioselective_Friedel_Crafts_Alkylation_Reactions_of_3_Substituted_Indoles_with_Electron_Deficient_Alkenes/3114916
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资源简介:
Highly enantioselective Friedel–Crafts
C2-alkylation reactions
of 3-substituted indoles with α,β-unsaturated esters and
nitroalkenes were developed using chiral Lewis acids as catalysts,
which afforded chiral indole derivatives bearing C2-benzylic stereogenic
centers in good to excellent yields (up to 99%) and enantioselectivities
(up to 96% ee).
创建时间:
2016-03-28



