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Sam68 regulation of alternative splicing in the developing cerebellum

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NIAID Data Ecosystem2026-03-12 收录
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We uncover a Sam68-dependent splicing program during cerebellar development. These events direct proper isoform expression of the genes required to guarantee the establishment of the correct spatial/temporal neural circuitry. The dysregulation in Sam68 null mice leads to functional defects in adult neurons Examination of 3 different RNA from P1, P10 and P30 wild type cerebella of mouse, and 2 from P1 and P10 Sam68 null cerebella

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2020-09-01
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