bulk mRNA-seq of Inpp5e mutant embryonic cortex against wild-type controls

Primary cilia act as antennas in cell-cell signalling and are crucial for nervous system development. We explored their role in the development of the murine cerebral cortex using mice mutant for the ciliary gene Inpp5e. We investigated the transcription profile of control and Inpp5e loss-of-function mutants in the E12.5 dorsal telencephalon.初级纤毛（Primary cilia）作为细胞间信号传导的天线，在神经系统发育中至关重要。本研究利用纤毛基因Inpp5e突变小鼠，探究了初级纤毛在小鼠大脑皮层发育中的作用。我们对胚胎期12.5天（E12.5）的背侧端脑组织中的对照组与Inpp5e功能丧失突变体的转录谱进行了分析。