Differential incubation times required for drug resistance generation.
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Leishmania promastigotes were incubated with increasing concentrations of edelfosine and miltefosine until parasite viability in the presence of 30 µM drug was over 80% (considered as drug resistant). The maximum period of time evaluated for acquisition of the resistant phenotype was 100 days, and no resistance to edelfosine was generated in L. donovani promastigotes after this incubation time. NR, no resistance.
创建时间：
2015-12-02
