IL12A:IL12B translocates from ER lumen to Golgi

Inferred from mouse :<br>Interleukin-12, (IL12) formed from Interleukin-12 subunit alpha (IL12A) and Interleukin-12 subunit beta (IL12B), has been localized intracellularly in late endocytic vesicles expresing the marker protein termed Vesicle-associated membrane protein 7 (VAMP7) (Chiaruttini et al. 2016).<br><br>This reaction is a black box event because we do not fully understand the mechanism of translocation.

从小鼠推断：由白细胞介素-12亚基α（IL12A）和白细胞介素-12亚基β（IL12B）组成的白细胞介素-12（IL12），在晚期内吞小泡中定位于表达标记蛋白称为囊泡相关膜蛋白7（VAMP7）的细胞内（参见Chiaruttini等，2016年）。该反应为一个黑盒事件，因为我们尚未完全理解其转运机制。